Idiopathic acquired sideroblastic anaemia transforming to acute myelosclerosis.

Prevalence and distribution of ringed sideroblasts in primary myelodysplastic syndromes.

In order to determine the prevalence and percentage distribution of ringed sideroblasts in primary myelodysplastic syndromes, the results of Prussian blue staining were analysed in 133 cases. Ringed sideroblasts ranging from 1 to 86% of cells were found in 76 (57%) cases. The cases of primary myelodysplastic syndrome corresponding to the group entitled "acquired idiopathic sideroblastic anaemia...

Primary acquired sideroblastic anaemia: response to treatment with pyridoxal-5-phosphate.

A 72-year-old woman with primary sideroblastic anaemia showed no response to treatment with pyridoxine. When she was given pyridoxal-5-phosphate there was a prompt reticulocyte response and sustained symptomatic improvement with satisfactory control of the anaemia.

Pleural extramedullary haematopoiesis in myelosclerosis.

DESPITE the extensive literature on myelosclerosis and extramedullary haematopoiesis (myeloid metaplasia), reference to the pleura as being the site of extramedullary haematopoiesis is not made in either the standard medical and pathology textbooks or in the radiological literature. We have recently encountered a case of myelosclerosis in which aspiration of what appeared on both clinical and r...

Defective neutrophil function and microbicidal mechanisms in the myelodysplastic disorders.

Neutrophil function studies have been carried out in a series of 44 patients with primary myelodysplastic syndromes (MDS). In vitro tests of phagocytosis and killing of Candida guilliermondii and Staphylococcus aureus identified 13 patients with abnormal neutrophil function at presentation and a further 10 who developed abnormalities during the course of their disease. The incidence of defectiv...

Acute transformation of a myeloproliferative state in sideroblastic anaemia with abnormal karyotype.